Monday, 5.6.2017 | ||||
Chairman: | Michal Hocek | |||
8:45 | 9:00 | M.Hocek | Opening | |
9:00 | 9:40 | PL1 | I. Willner | Nucleic Acid Nanostructures Exhibiting Programmed Machinery and Catalytic Functionalities |
9:40 | 10:20 | PL2 | N. Sugimoto | Non-canonical World of Nucleic Acids under Molecular Crowding |
10:20 | 10:50 | Coffee Break | ||
Chairman: | Scott Silverman | |||
10:50 | 11:20 | EYIL1 | C. Höbartner | The structural basis of DNA catalysis and fluorogenic labeling of RNA modifications |
11:20 | 11:40 | OC1 | D. Sen | In vitro selected DNAzymes and ribozymes and their links to biology |
11:40 | 12:00 | OC2 | A. Fleming | 4n-1 is a “Sweet Spot” in 2’-Deoxycytidine Homopolymers adopting i-motif folds |
12:00 | 12:20 | OC3 | E. Funder | New Discoveries within Phosphorothioate LNA |
12:20 | 12:40 | OC4 | A. Istrate | Manipulating the properties of tricyclo-DNA by 2′-fluorination |
12:40 | 14:30 | Lunch | ||
Chairman: | Nathan Luedtke | |||
14:30 | 15:30 | Sorm Award | A. Marx | Copying of unnatural and natural nucleic acid modifications |
15:30 | 15:50 | OC5 | M. Hocek | DNA Modifications for Sensing, Cross-linking or Switching of DNA-Protein Interactions |
15:50 | 16:10 | OC6 | M. Hollenstein | Synthesis of modified nucleoside triphosphates for selection experiments |
16:10 | 16:30 | Coffee Break | ||
Chairman: | Oliver Seitz | |||
16:30 | 17:10 | PL3 | S. Silverman | DNA as an Enzyme |
17:10 | 17:30 | OC7 | M. Kuwahara | Simple Method for Biomarker Detection: Signal Amplification by Ternary Initiation Complexes |
17:30 | 17:50 | OC8 | D. Perrin | DNAzymes and Aptamers with Protein-like Functionalities Derived from Modified dNTPs |
17:50 | 18:10 | OC9 | C. K. O' Sullivan | Selection, characterisation and analytical application of DNA aptamers against the anaphylactic allergen, Lup-an 1, ß-conglutin |
18:10 | 18:30 | OC10 | J. Spacek | Detection of brand new unnatural base pairs in in vivo prepared plasmid DNA by electrochemistry with the good old hanging mercury drop electrode |
19:00 | 22:00 | Jena Bioscience Beer Party and Dinner | ||
Tuesday, 6.6.2017 | ||||
Chairman: | Andreas Marx | |||
9:00 | 9:40 | PL4 | T. Carell | DNA bases beyond Watson and Crick |
9:40 | 10:00 | OC11 | S. Becker | Formation of purine nucleosides and its modifications under plausible prebiotic conditions |
10:00 | 10:20 | OC12 | H. Sugiyama | Chemical Biology of Nucleic Acids: DNA Origami and Artificial Genetic Switch |
10:20 | 10:50 | Coffee Break | ||
Chairman: | Thomas Carell | |||
10:50 | 11:20 | EYIL2 | N. W. Luedtke | A Bioorthogonal Chemical Reporter of Nucleoside Drug Metabolism |
11:20 | 11:40 | OC13 | A. Granzhan | Macrocyclic DNA Ligands: Smart DNA-Lesion Binders and Inhibitors of DNA Repair |
11:40 | 12:00 | OC14 | A. Madder | Modified nucleic acids for crosslinking and catalysis |
12:00 | 12:20 | OC15 | B. Y. Michel | Dynamics of 5-MethylCytosine Flipping by UHRF1: How Long Does It Take to Convey an Epigenetic Mark? |
12:20 | 12:40 | OC16 | T. Lavergne | Topologically controlled G-quadruplex foldamers: design and application |
12:40 | 14:30 | Lunch | ||
Chairman: | Hans-Achim Wagenknecht | |||
15:30 | 15:10 | PL5 | C. Meier | Developing Prodrugs of antivirally active Nucleoside Triphosphates - Against all odds, it works! |
15:10 | 15:30 | OC17 | S. Vasilyeva | SiO2 nanoparticles as a vehicle for delivery of nucleoside triphosphate analogues into cells |
15:30 | 15:50 | OC18 | T. Kraus | Synthetic transporters of modified nucleoside triphosphates across cell membranes |
15:50 | 16:10 | OC19 | P. Kumar | Triazole –linked Locked Nucleic Acids: Synthesis and Hybridization Properties |
16:10 | 16:30 | OC20 | J. Brčić | DNA oligonucleotide with GGGGCC repeats implicated in ALS and FTD folds into two distinct G-quadruplex structures |
16:30 | 21:30 | Alios Biopharma Poster Session and Dinner | ||
Wednesday, 7.6.2017 | ||||
Chairman: | Chris Meier | |||
9:00 | 9:40 | PL6 | R. Schinazi | Development of Ideal Pangenotypic HCV Regimens |
9:40 | 10:00 | OC21 | R. Nencka | Nucleoside inhibitors of arthropod-borne flaviviruses |
10:00 | 10:20 | OC22 | A. M. Downey | Progress Toward Protecting Group-Free Synthesis of Nucleosides |
10:20 | 10:50 | Coffee Break | ||
Chairman: | Annemieke Madder | |||
10:50 | 11:20 | EYIL3 | J. Kowalska | Exploring „clickable” phosphate analogs to create biologically-active nucleotide mimics and probes |
11:20 | 11:40 | OC23 | M. Warminski | Structural studies on therapeutically relevant mRNA 5’ cap analogues in complexes with eukaryotic translation initiation factor 4E by X-Ray crystallography |
11:40 | 12:00 | OC23 | M. Manoharan | Chemically modified siRNAs for human therapeutics |
12:00 | 12:20 | OC25 | P. Nielsen | Double-headed nucleotides – condensing the information |
12:20 | 12:40 | OC26 | M. De Fenza | Novel Piperidinyl Iminosugar-Based Nucleosides as Selective Pharmacological Tools |
12:40 | 14:00 | Lunch | ||
14:00 | 20:00 | Free afternoon | ||
20:00 | 24:00:00 | Chemgenes Conference Dinner | ||
Thursday, 7.6.2017 | ||||
Chairman: | Cynthia Burrows | |||
9:00 | 9:40 | PL7 | K. V. Gothelf | Templated Assembly of Polymers and other Materials |
9:40 | 10:00 | OC27 | H.-A. Wagenknecht | Light-drivenm functions in DNA |
10:00 | 10:20 | OC28 | L. M. Wilhelmsson | Nucleic acid base analogue FRET |
10:20 | 10:50 | Coffee Break | ||
Chairman: | Kurt Gothelf | |||
10:50 | 11:20 | EYIL4 | A. Rentmeister | Chemo-enzymatic modification of eukaryotic mRNAs |
11:20 | 11:40 | OC29 | S. Seergazhi Gopalan | Probing Nucleic Acid Structure and Function Using Multifunctional Nucleoside Analog Probes |
11:40 | 12:00 | OC30 | E. Westhof | An integrated, structure- and energy-based view of the genetic code |
12:00 | 12:20 | OC31 | B. Nawrot | Non-canonical base pairs in codon-anticodon recognition |
12:20 | 12:40 | OC32 | G. Leszczynska | Why Nature introduced S-geranyl to the wobble 2-thiouridines of transfer RNAs |
12:40 | 14:30 | Lunch | ||
Chairman: | Eric Westhof | |||
14:30 | 15:10 | PL8 | C. Richert | RNA-Induced Formation of Peptides in the Absence of Enzymes |
15:10 | 15:30 | OC33 | J.-L. Mergny | Quadruplexes are everywhere! |
15:30 | 15:50 | OC34 | O. Seitz | Exploring Multivalency by DNA-programmed spatial screening |
15:50 | 16:10 | OC35 | A. Kellett | Polynuclear Metallodrug—Nucleic Acid Interactions: New Therapeutic and Biochemical Applications |
16:10 | 16:30 | Coffee Break | ||
Chairman: | Jean-Louis Mergny | |||
16:30 | 16:50 | OC36 | A. Ono | Characterization of Duplexes containing metal ion mediated base pairs |
16:50 | 17:10 | OC37 | M. Smietana | Remote control of RNase H activity using the boronic acid/boronate ester switch |
17:10 | 17:30 | OC38 | M. Caruthers | Synthesis, Biochemistry, and Biology of New Morpholino and Thiomorpholino DNA Analogues |
17:30 | 18:10 | PL9 | C. Burrows | Epigenetics of Guanine |
18:10 | 18:30 | M.Hocek | Concluding remarks | |
19:00 | 20:00 | Organ Concert | ||
20:00 | 21:30 | Dinner |
Org.No. | Surname | Name | Title |
P 01 | Alexandrova | Liudmila | New 4-Modified cytidines: synthesis and evaluation as antimicrobial agents |
P 02 | Alibayov | Babek | Application of NAD captureSeq on viruses |
P 03 | Baszczyňski | Ondřej | Phosphonoacetate analogues of adenosine 5'-diphosphate ribose (ADPR): probes for the Transient Receptor Potential (TRP) cation channel TRPM2 |
P 04 | Benoni | Roberto | Mapping of m1A in the viral RNA |
P 05 | Berger | Florence | Fluorescent Modified Guanine Nucleotides to Probe Frameshift Mutations in DNA |
P 06 | Boháčová | Soňa | Nucleotides Bearing Photocleavable Groups for DNA Photocaging |
P 07 | Bood | Mattias | A highly emissive adenine analogue with promising properties for microscopy |
P 08 | Brehova | Petra | Synthesis of acyclic nucleoside phosphonates with unnatural heterocyclic bases bearing aryl substituents and their inhibitory activity towards bacterial and human adenylate cyclases |
P 09 | Brzezińska | Jolanta | Thermo-controlled Device in Orthogonal Protection Strategy for Bioconjugate Synthesis |
P 10 | Cechova | Lucie | 5-Azopyrimidines: Synthesis and NMR study of their photochemical behavior |
P 11 | Cesnek | Michal | Synthesis and evaluation of novel acyclic nucleoside phosphonates with unnatural nucleobases as potent inhibitors of Bordetella pertussis adenylate cyclase toxin |
P 12 | Chmielewski | Marcin | Stereoselective Cyclisation and Diastereoisomeric Purification of 3-(Pyridin-2-yl)-1-phenyl-(1,3,2)oxazaphospholidine Formed from a Thermolabile Protecting Group |
P 13 | Croce | Stefano | EdU DetectPro |
P 14 | Debart | Francoise | 2’-O-modified siRNA by disulfide-containing groups in a prodrug approach |
P 15 | Drenichev | Mikhail S. | Synthesis and antiviral activity of N6-substituted adenosine derivatives |
P 16 | Ebenryter-Olbinska | Katarzyna | Synthesis and physicochemical characterization of antisense oligonucleotides modified with boron clusters |
P 17 | Ermert | Susanne | Development of ATP-based Signaling Molecules |
P 18 | Esposito | Anna | Synthesis and Biological Evaluation of D- and L- Cyclohexenyl Nucleosides |
P 19 | Evéquoz | Damien | Exploring the backbone topology of DNA: the 7',5'-bicyclo-DNA system |
P 20 | Fantoni | Nicolo | Artificial Metallo-Nucleases for Gene Editing |
P 21 | Fignole | Klavdja | Synthesis and biophysical properties of C(6’)-modified tricyclo-DNA analogs |
P 22 | Fojta | Miroslav | Utilization of Catalytic Hydrogen Evolution in Electrochemical Analysis of Modified Nucleic Acids |
P 23 | Frei | Sibylle | Synthesis and Properties of Novel Fluorinated Bicyclic Nucleosides and Oligonucleotides |
P 24 | Gadakh | Bharat | Pharmacophoric importance of the adenine base in aminoacyl-sulfamoyl analogues (aaSAs) |
P 25 | Gasser | Catherina | Syntheses of S-adenosylmethionine (SAM) analogues – Towards alternative ligands for SAM riboswitches |
P 26 | Gołębiewska | Justyna | A new, efficient entry for the preparation of nucleoside 5'-phosphoramidates - as new substrates for the synthesis of biologically active nucleoside 5'-diphosphates |
P 27 | Güixens-Gallardo | Pedro | Synthesis of new fluorescent nucleosides through the Knoevenagel condensation and related reactions. |
P 28 | Hagiwara | Kenta | Reusable Enzymatic Production System for Artificial Nucleic Acids |
P 29 | Höbartner | Claudia | Fluorescence activating RNA aptamers |
P 30 | Hockova | Dana | Acyclic nucleoside phosphonates: Inhibition and structural investigations of Trypanosoma brucei 6-oxopurine phosphoribosyltranferases |
P 31 | Hudeček | Oldřich | Development of capturing technique for 5’-diphosphate RNA |
P 32 | Jankowska-Anyszka | Marzena | Synthesis and potential application of new double-functionalized dinucleotide mRNA cap analogues |
P 33 | Jastrzebska | Katarzyna | P-stereodefined homopurine chimeric [All-RP-PS]-DNA#LNA oligomers recruit Hoogsteen-paired DNA templates to form thermally stable parallel complexes |
P 34 | Jemielity | Jacek | 5’ mRNA Cap Analogs for Efficient Translation and Specific Labeling of mRNA in Living Cells |
P 35 | Kaiser | Martin Maxmilian | Acyclic nucleoside phosphonates with (S)- and (R)-HPEP moiety as monomers for the synthesis of modified oligonucleotides |
P 36 | Kaniowski | Damian | Anti-EGFR silencing activity of antisense oligonucleotides labeled with boron clusters |
P 37 | Khandazhinskaya | Anastasia | Novel 5’-Norcarbocyclic Nucleoside Analogues As Antibacterial Agents |
P 38 | Kirillova | Yuliya | Synthesis of polyanionic ?-PNAs derived from L-Glu |
P 39 | Klejch | Tomáš | Acyclic nucleoside phosphonates bearing Favipiravir as a nucleobase: Potential inhibitors of hypoxanthine-guanine phosphoribosyltransferase |
P 40 | Koćmik | Ilona | Synthesis and biological evaluation of dinucleotide analogues of 5' end of the mRNA modified at the N2 and C2' (C3') positions of 7-methylguanosine |
P 41 | Kočišek | Jaroslav | DNA Binding Radiosensitizers and Low Energy Electrons |
P 42 | Kropp | Heike | Unraveling the interactions between a modified primer and KlenTaq DNA polymerase - on a structural level |
P 43 | Kryńska | Paulina | Reversible functionalization of sulfur containing guanosine derivatives |
P 44 | Lange | Sandra | Exploring Interaction Partners of Diadenosine Triphosphate |
P 45 | Lehner | Maike | Synthesis and Investigation of Cell-Permeable NAD+ Analogs |
P 46 | Leitner | Kim | DNA polymerase-based systems for site-specific sensing of the presence or absence of DNA modifications |
P 47 | Luo | Min | Expanding the Antiviral Spectrum of Fluorinated Acyclic Nucleoside Phosphonates (FPMPs): Diamyl Aspartate Amidate Prodrugs |
P 48 | Maciaszek | Anna | P-Diastereomers of the oxathiaphospholane derivatives of N6-methyl-2’-deoxyadenosine and N2,N2-dimethyl-2’-deoxyguanosine–discriminators of Watson-Crick interactions in parallel triplexes. |
P 49 | Mairhofer | Elisabeth | Towards the efficient synthesis of arginine-containing peptidyl-tRNA mimics |
P 50 | Manicardi | Alex | Crosslinking Peptide Nucleic Acids (PNAs) for DNA targeting |
P 51 | Matyašovský | Ján | 2-Substituted dATP Derivatives as Building Blocks for Polymerase Catalyzed Synthesis of DNA Modified in the Minor Groove |
P 52 | Matyugina | Elena | Design and synthesis of novel fleximers |
P 53 | Mikhailov | Sergey | Synthesis of purines from nucleosides: ribose as a blocking group |
P 54 | Milisavljevic | Nemanja | Enzymatic synthesis of base-modified RNAs |
P 55 | Morvan | Francois | Double Oxime Ligation for the Synthesis of Circular Oligonucleotides |
P 56 | Muttach | Fabian | Novel AdoMet analogues as tools for enzymatic transfer of photo-crosslinkers and capturing RNA-protein interactions |
P 57 | Nautiyal | Manesh | Biological and structural analysis of base modified nucleosides as aminoacyl adenylate analogues inhibiting tRNA synthetases |
P 58 | Negrya | Sergey | Synthesis and biological properties of modified 2’-deoxyuridines with broad spectrum of antimicrobial activity |
P 59 | Olszewska | Agata | Development of reactive groups for DNA-protein cross-link information |
P 60 | Oslovsky | Vladimir | Synthesis and antiviral activity of new N6-benzyladenosine analogues with acetylene linker |
P 61 | Panattoni | Alessandro | Competitive primer extension of base-modified dNTPs in the presence of natural dNTPs. |
P 62 | Perlikova | Pavla | Mechanism of action of 7-(2-thienyl)-7-deazaadenosine (AB61), a potent cytostatic |
P 63 | Piecyk | Karolina Ewa | Synthesis and potencial application of new double-functionalized dinucleotide mRNA cap analogues |
P 64 | Ploschik | Damian | Enzymatic Synthesis and Copperfree Bioorthogonal Labeling of Cyclopropene-modified Oligonucleotides by the Use of Inverse Electron Demand Diels-Alder Cycloaddition |
P 65 | Pozmogova | Galina | A THF-based modification induces antiparallel to parallel conformational switches in G4 DNA |
P 66 | Promontorio | Rossella | Exploration of new chemical space through the synthesis of sp3-enriched bridged bicyclo compounds |
P 67 | Promontorio | Rossella | Crystal structure of an intramolecular telomeric DNA G-quadruplex-ligand complex |
P 68 | Rachwalak | Marta | Synthesis of nucleoside 5'-diphosphates and their tio- and seleno analogues using H-phosphonate chemistry |
P 69 | Rahimoff | René | A novel probe for the MS/MS-based detection and quantification of abasic site intermediates in genomic DNA |
P 70 | Ravn | Jacob | Conjugation and linker strategies for LNA SSO delivery |
P 71 | Räz | Michael | Torsional Constraints of DNA Substrates Impact Cas9 Cleavage |
P 72 | Reichle | Valentin Frederik | Biosynthetic isotope labeling reveals dynamics of the epitranscriptome and novel modified nucleosides |
P 73 | Reisacher | Ulrike | Copper-free, Bioorthogonal and Postsynthetic Labeling of Nucleic Acids |
P 74 | Richard | Jean-Alexandre | Synthesis of dihydroxanthene near-infrared emitting fluorophores and their water-soluble analogues |
P 75 | Romanowska | Joanna | Exploring new anti-HIV prodrugs – nucleoside 5’-diphosphates |
P 76 | Rydzik | Anna | Crosslinking strategies for capturing nucleic acid – protein interactions |
P 77 | Saha | Subham | Noncovalent Spin Labeling of Unmodified RNA: The Aptamer Approach |
P 78 | Schiffers | Sarah | Quantitative LC-MS provides no evidence for m6dA or m4dC in the genomes of mouse ESCs and tissues |
P 79 | Schmidt | Olivia Paula | A Fluorescent Base Analog Reveals High Kinetic Stabilities of T-HgII-T Base Pairs that Inhibit DNA Dynamics and Polymerase Activity |
P 80 | Schneider | Christina | Ubiquitous non-canonical RNA nucleosides are vestiges of the early Earth |
P 81 | Sherstyuk | Yuliya | ADP conjugates as potential PARP-1 inhibitors |
P 82 | Shin | Dongwon | Novel N1-Substituted Pseudouridine 5’-Triphosphates for the Synthesis of Modified mRNA and its Effect on mRNA Translation in THP-1 cells |
P 83 | Simonova | Anna | Phenothiazine as new oxidizable label for electrochemical detection of DNA |
P 84 | Skácel | Jan | Design and Synthesis of Potential HG(X)PRT Inhibitors Based on Polysubstituted Thiophenes: Utilization of Direct Metalation of Heterocycles. |
P 85 | Slator | Creina | Di-Copper Complexes Promote NCI-60 Chemotherapy by Intracellular Superoxide and Singlet Oxygen Facilitated DNA Damage |
P 86 | Slavíčková | Michaela | Synthesis of hydrophobic derivatives of 2'-deoxyadenosine and DNA |
P 87 | Soudah | Terese | PNA-peptide conjugates as splice switching oligonucleotides (SSO) of the MnK2 gene |
P 88 | Stazzoni | Samuele | Quantification of 5-formylcytosine in specific genomic sites |
P 89 | Šimonová | Anna | Studies of methylation of viral RNA |
P 90 | Špaček | Petr | Acyclic nucleoside bisphosphonates with asymmetric scaffold as inhibitors of Plasmodial and human 6-oxopurine phosphoribosyltransferases |
P 91 | Tichý | Michal | Synthesis and Biological Activities of Thieno-fused 7-Deazapurine Ribonucleosides |
P 92 | Varizhuk | Anna | New benzothiazole-derived dyes for staining of non-canonical DNA |
P 93 | Walczak | Sylwia | Triazole-modified dinucleotides as 5’ mRNA cap mimics and reagents for mRNA modification |
P 94 | Wanat | Przemyslaw | Nonhydrolyzable pyrene-excimer NTP-based molecular probes |
P 95 | Watanabe | Yurika | Water-Soluble Nucleotide Analogue (WSNA) with a Flexible Backbone-Containing Guanidinium Groups |
P 96 | Witkowska | Agnieszka | Chemical Switch in 2-Pyridinyl Thermolabile Protecting groups methodology |
P 97 | Zatsepin | Timofey | Specificity of SNP detection with molecular beacons is improved by stem and loop separation with spacers |